Publications

Publication list also available at NCBI.

Nikonorova IA, Zhu Q, Signore CC, Mirek ET, Jonsson WO, Kong B, Guo GL, Belden WJ, Anthony TG. Age modulates liver responses to asparaginase-induced amino acid stress in mice. J Biol Chem. 2019 Sep 20;294(38):13864-13875. doi: 10.1074/jbc.RA119.009864. Epub 2019 Aug 14. PubMed PMID: 31413113; PubMed Central PMCID: PMC6755797.

Jonsson WO, Margolies NS, Anthony TG. Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights. Nutrients. 2019 Jun 15;11(6). doi: 10.3390/nu11061349. Review. PubMed PMID: 31208042; PubMed Central PMCID: PMC6627990.

Neinast MD, Jang C, Hui S, Murashige DS, Chu Q, Morscher RJ, Li X, Zhan L, White E, Anthony TG, Rabinowitz JD, Arany Z. Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. Cell Metab. 2019 Feb 5;29(2):417-429.e4. doi: 10.1016/j.cmet.2018.10.013. Epub 2018 Nov 15. PubMed PMID: 30449684; PubMed Central PMCID: PMC6365191.

Yimcharoen M, Kittikunnathum S, Suknikorn C, Nak-On W, Yeethong P, Anthony TG, Bunpo P. Effects of ascorbic acid supplementation on oxidative stress markers in healthy women following a single bout of exercise. J Int Soc Sports Nutr. 2019 Jan 21;16(1):2. doi: 10.1186/s12970-019-0269-8. PubMed PMID: 30665439; PubMed Central PMCID: PMC6341721.

Tuazon MA, Campbell SC, Klein DJ, Shapses SA, Anacker KR, Anthony TG, Uzumcu M, Henderson GC. Effects of ovariectomy and exercise training intensity on energy substrate and hepatic lipid metabolism, and spontaneous physical activity in mice. Metabolism. 2018 Jun;83:234-244. doi: 10.1016/j.metabol.2018.02.011. Epub 2018 Mar 6. PubMed PMID: 29522773.

Nikonorova IA, Mirek ET, Signore CC, Goudie MP, Wek RC, Anthony TG. Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver. J Biol Chem. 2018 Apr 6;293(14):5005-5015. doi: 10.1074/jbc.RA117.001625. Epub 2018 Feb 15. PubMed PMID: 29449374; PubMed Central PMCID: PMC5892569.

Pettit AP, Jonsson WO, Bargoud AR, Mirek ET, Peelor FF 3rd, Wang Y, Gettys TW, Kimball SR, Miller BF, Hamilton KL, Wek RC, Anthony TG. Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice. J Nutr. 2017 Jun;147(6):1031-1040. doi: 10.3945/jn.116.246710. Epub 2017 Apr 26. PubMed PMID: 28446632; PubMed Central PMCID: PMC5443467.

Al-Baghdadi RJT, Nikonorova IA, Mirek ET, Wang Y, Park J, Belden WJ, Wek RC, Anthony TG. Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase. Sci Rep. 2017 Apr 28;7(1):1272. doi: 10.1038/s41598-017-01041-7. PubMed PMID: 28455513; PubMed Central PMCID: PMC5430736.

Nikonorova IA, Al-Baghdadi RJT, Mirek ET, Wang Y, Goudie MP, Wetstein BB, Dixon JL, Hine C, Mitchell JR, Adams CM, Wek RC, Anthony TG. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice. J Biol Chem. 2017 Apr 21;292(16):6786-6798. doi: 10.1074/jbc.M116.768408. Epub 2017 Feb 27. PubMed PMID: 28242759; PubMed Central PMCID: PMC5399125.

Gietzen DW, Anthony TG, Fafournoux P, Maurin AC, Koehnle TJ, Hao S. Measuring the Ability of Mice to Sense Dietary Essential Amino Acid Deficiency: The Importance of Amino Acid Status and Timing. Cell Rep. 2016 Aug 23;16(8):2049-2050. doi: 10.1016/j.celrep.2016.08.021. PubMed PMID: 27558824.

Anthony TG. Mechanisms of protein balance in skeletal muscle. Domest Anim Endocrinol. 2016 Jul;56 Suppl:S23-32. doi: 10.1016/j.domaniend.2016.02.012. Review. PubMed PMID: 27345321; PubMed Central PMCID: PMC4926040.

Phillipson-Weiner L, Mirek ET, Wang Y, McAuliffe WG, Wek RC, Anthony TG. General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1061-70. doi: 10.1152/ajpgi.00052.2016. Epub 2016 Mar 11. PubMed PMID: 26968207; PubMed Central PMCID: PMC4935488.

Wanders D, Stone KP, Forney LA, Cortez CC, Dille KN, Simon J, Xu M, Hotard EC, Nikonorova IA, Pettit AP, Anthony TG, Gettys TW. Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction. Diabetes. 2016 Jun;65(6):1499-510. doi: 10.2337/db15-1324. Epub 2016 Mar 2. PubMed PMID: 26936965; PubMed Central PMCID: PMC4878423.

Fusakio ME, Willy JA, Wang Y, Mirek ET, Al Baghdadi RJ, Adams CM, Anthony TG, Wek RC. Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver. Mol Biol Cell. 2016 May 1;27(9):1536-51. doi: 10.1091/mbc.E16-01-0039. Epub 2016 Mar 9. PubMed PMID: 26960794; PubMed Central PMCID: PMC4850040.

Bunpo P, Anthony TG. Ascorbic acid supplementation does not alter oxidative stress markers in healthy volunteers engaged in a supervised exercise program. Appl Physiol Nutr Metab. 2016 Feb;41(2):175-80. doi: 10.1139/apnm-2015-0285. Epub 2015 Oct 26. PubMed PMID: 26789096.

Duan Y, Li F, Li Y, Tang Y, Kong X, Feng Z, Anthony TG, Watford M, Hou Y, Wu G, Yin Y. The role of leucine and its metabolites in protein and energy metabolism. Amino Acids. 2016 Jan;48(1):41-51. doi: 10.1007/s00726-015-2067-1. Epub 2015 Aug 9. Review. PubMed PMID: 26255285.

Anthony TG, Mirek ET, Bargoud AR, Phillipson-Weiner L, DeOliveira CM, Wetstein B, Graf BL, Kuhn PE, Raskin I. Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats. Appl Physiol Nutr Metab. 2015 Dec;40(12):1324-8. doi: 10.1139/apnm-2015-0301. Epub 2015 Sep 17. PubMed PMID: 26584207.

Layman DK, Anthony TG, Rasmussen BB, Adams SH, Lynch CJ, Brinkworth GD, Davis TA. Defining meal requirements for protein to optimize metabolic roles of amino acids. Am J Clin Nutr. 2015 Jun;101(6):1330S-1338S. doi: 10.3945/ajcn.114.084053. Epub 2015 Apr 29. PubMed PMID: 25926513; PubMed Central PMCID: PMC5278948.

Wilson GJ, Lennox BA, She P, Mirek ET, Al Baghdadi RJ, Fusakio ME, Dixon JL, Henderson GC, Wek RC, Anthony TG. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E283-93. doi: 10.1152/ajpendo.00361.2014. Epub 2014 Dec 9. PubMed PMID: 25491724; PubMed Central PMCID: PMC4329494.

Tuazon MA, McConnell TR, Wilson GJ, Anthony TG, Henderson GC. Intensity-dependent and sex-specific alterations in hepatic triglyceride metabolism in mice following acute exercise. J Appl Physiol (1985). 2015 Jan 1;118(1):61-70. doi: 10.1152/japplphysiol.00440.2014. Epub 2014 Sep 25. PubMed PMID: 25257878; PubMed Central PMCID: PMC6195669.

Baird TD, Palam LR, Fusakio ME, Willy JA, Davis CM, McClintick JN, Anthony TG, Wek RC. Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα. Mol Biol Cell. 2014 May;25(10):1686-97. doi: 10.1091/mbc.E14-02-0704. Epub 2014 Mar 19. PubMed PMID: 24648495; PubMed Central PMCID: PMC4019499.

Wilson GJ, Bunpo P, Cundiff JK, Wek RC, Anthony TG. The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1124-33. doi: 10.1152/ajpendo.00080.2013. Epub 2013 Sep 3. PubMed PMID: 24002574; PubMed Central PMCID: PMC3840205.

She P, Bunpo P, Cundiff JK, Wek RC, Harris RA, Anthony TG. General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice. J Biol Chem. 2013 Oct 25;288(43):31250-60. doi: 10.1074/jbc.M113.498469. Epub 2013 Sep 9. PubMed PMID: 24019515; PubMed Central PMCID: PMC3829435.

Anthony TG, Morrison CD, Gettys TW. Remodeling of lipid metabolism by dietary restriction of essential amino acids. Diabetes. 2013 Aug;62(8):2635-44. doi: 10.2337/db12-1613. Review. PubMed PMID: 23881190; PubMed Central PMCID: PMC3717867.

Lackey DE, Lynch CJ, Olson KC, Mostaedi R, Ali M, Smith WH, Karpe F, Humphreys S, Bedinger DH, Dunn TN, Thomas AP, Oort PJ, Kieffer DA, Amin R, Bettaieb A, Haj FG, Permana P, Anthony TG, Adams SH. Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab. 2013 Jun 1;304(11):E1175-87. doi: 10.1152/ajpendo.00630.2012. Epub 2013 Mar 19. PubMed PMID: 23512805; PubMed Central PMCID: PMC3680678.

Anthony TG, Gietzen DW. Detection of amino acid deprivation in the central nervous system. Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):96-101. doi: 10.1097/MCO.0b013e32835b618b. Review. PubMed PMID: 23222708.

Wilson GJ, Moulton CJ, Garlick PJ, Anthony TG, Layman DK. Post-meal responses of elongation factor 2 (eEF2) and adenosine monophosphate-activated protein kinase (AMPK) to leucine and carbohydrate supplements for regulating protein synthesis duration and energy homeostasis in rat skeletal muscle. Nutrients. 2012 Nov 13;4(11):1723-39. doi: 10.3390/nu4111723. PubMed PMID: 23201843; PubMed Central PMCID: PMC3509516.

Shan J, Fu L, Balasubramanian MN, Anthony T, Kilberg MS. ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. J Biol Chem. 2012 Oct 19;287(43):36393-403. doi: 10.1074/jbc.M112.399600. Epub 2012 Sep 6. PubMed PMID: 22955275; PubMed Central PMCID: PMC3476305.

Anthony TG, Wek RC. TXNIP switches tracks toward a terminal UPR. Cell Metab. 2012 Aug 8;16(2):135-7. doi: 10.1016/j.cmet.2012.07.012. PubMed PMID: 22883225.

Wilson GJ, Layman DK, Moulton CJ, Norton LE, Anthony TG, Proud CG, Rupassara SI, Garlick PJ. Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats. Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1236-42. doi: 10.1152/ajpendo.00242.2011. Epub 2011 Sep 13. PubMed PMID: 21917636; PubMed Central PMCID: PMC4395871.

Teske BF, Wek SA, Bunpo P, Cundiff JK, McClintick JN, Anthony TG, Wek RC. The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Mol Biol Cell. 2011 Nov;22(22):4390-405. doi: 10.1091/mbc.E11-06-0510. Epub 2011 Sep 14. PubMed PMID: 21917591; PubMed Central PMCID: PMC3216664.

Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG. The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. J Nutr. 2010 Nov;140(11):2020-7. doi: 10.3945/jn.110.129197. Epub 2010 Sep 22. PubMed PMID: 20861212; PubMed Central PMCID: PMC2955878.

Wek RC, Anthony TG. Obesity: stressing about unfolded proteins. Nat Med. 2010 Apr;16(4):374-6. doi: 10.1038/nm0410-374. PubMed PMID: 20376042.

Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG. GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. J Biol Chem. 2009 Nov 20;284(47):32742-9. doi: 10.1074/jbc.M109.047910. Epub 2009 Sep 25. PubMed PMID: 19783659; PubMed Central PMCID: PMC2781691.

Wek RC, Anthony TG. Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention. Cell Metab. 2009 Jul;10(1):1-2. doi: 10.1016/j.cmet.2009.06.005. PubMed PMID: 19583945.

Norton LE, Layman DK, Bunpo P, Anthony TG, Brana DV, Garlick PJ. The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats. J Nutr. 2009 Jun;139(6):1103-9. doi: 10.3945/jn.108.103853. Epub 2009 Apr 29. PubMed PMID: 19403715.

Anthony TG, Anthony JC. AMPing down leucine action in skeletal muscle. J Nutr. 2008 Dec;138(12):2307-8. doi: 10.3945/jn.108.098392. PubMed PMID: 19022949.

Bunpo P, Murray B, Cundiff J, Brizius E, Aldrich CJ, Anthony TG. Alanyl-glutamine consumption modifies the suppressive effect of L-asparaginase on lymphocyte populations in mice. J Nutr. 2008 Feb;138(2):338-43. doi: 10.1093/jn/138.2.338. PubMed PMID: 18203901.

Anthony TG, McDaniel BJ, Knoll P, Bunpo P, Paul GL, McNurlan MA. Feeding meals containing soy or whey protein after exercise stimulates protein synthesis and translation initiation in the skeletal muscle of male rats. J Nutr. 2007 Feb;137(2):357-62. doi: 10.1093/jn/137.2.357. PubMed PMID: 17237311.

Gietzen DW, Hao S, Anthony TG. Mechanisms of food intake repression in indispensable amino acid deficiency. Annu Rev Nutr. 2007;27:63-78. doi: 10.1146/annurev.nutr.27.061406.093726. Review. PubMed PMID: 17328672.

Wek RC, Anthony TG. EXtENDINg beta cell survival by UPRegulating ATF4 translation. Cell Metab. 2006 Nov;4(5):333-4. doi: 10.1016/j.cmet.2006.10.006. Review. PubMed PMID: 17084705.

Reinert RB, Oberle LM, Wek SA, Bunpo P, Wang XP, Mileva I, Goodwin LO, Aldrich CJ, Durden DL, McNurlan MA, Wek RC, Anthony TG. Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase. J Biol Chem. 2006 Oct 20;281(42):31222-33. doi: 10.1074/jbc.M604511200. Epub 2006 Aug 24. PubMed PMID: 16931516.

Wek RC, Jiang HY, Anthony TG. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans. 2006 Feb;34(Pt 1):7-11. doi: 10.1042/BST20060007. Review. PubMed PMID: 16246168.

Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, Cavener DR, McGrath BC, Rudell JB, Koehnle TJ, Gietzen DW. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science. 2005 Mar 18;307(5716):1776-8. doi: 10.1126/science.1104882. PubMed PMID: 15774759.

Baum JI, O’Connor JC, Seyler JE, Anthony TG, Freund GG, Layman DK. Leucine reduces the duration of insulin-induced PI 3-kinase activity in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E86-91. doi: 10.1152/ajpendo.00272.2004. Epub 2004 Aug 31. PubMed PMID: 15339747.

Reiter AK, Anthony TG, Anthony JC, Jefferson LS, Kimball SR. The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver. Int J Biochem Cell Biol. 2004 Nov;36(11):2169-79. doi: 10.1016/j.biocel.2004.04.004. PubMed PMID: 15313464.

Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC. Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem. 2004 Aug 27;279(35):36553-61. doi: 10.1074/jbc.M404559200. Epub 2004 Jun 22. PubMed PMID: 15213227.

Crozier SJ, Anthony JC, Schworer CM, Reiter AK, Anthony TG, Kimball SR, Jefferson LS. Tissue-specific regulation of protein synthesis by insulin and free fatty acids. Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E754-62. doi: 10.1152/ajpendo.00063.2003. Epub 2003 Jul 1. PubMed PMID: 12837665.

Kobayashi H, Børsheim E, Anthony TG, Traber DL, Badalamenti J, Kimball SR, Jefferson LS, Wolfe RR. Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E488-98. doi: 10.1152/ajpendo.00094.2002. PubMed PMID: 12556349.

Anthony JC, Lang CH, Crozier SJ, Anthony TG, MacLean DA, Kimball SR, Jefferson LS. Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am J Physiol Endocrinol Metab. 2002 May;282(5):E1092-101. doi: 10.1152/ajpendo.00208.2001. PubMed PMID: 11934675.

Anthony JC, Reiter AK, Anthony TG, Crozier SJ, Lang CH, MacLean DA, Kimball SR, Jefferson LS. Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes. 2002 Apr;51(4):928-36. doi: 10.2337/diabetes.51.4.928. PubMed PMID: 11916909.

Anthony TG, Reiter AK, Anthony JC, Kimball SR, Jefferson LS. Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats. Am J Physiol Endocrinol Metab. 2001 Sep;281(3):E430-9. doi: 10.1152/ajpendo.2001.281.3.E430. PubMed PMID: 11500297.

Anthony TG, Anthony JC, Yoshizawa F, Kimball SR, Jefferson LS. Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats. J Nutr. 2001 Apr;131(4):1171-6. doi: 10.1093/jn/131.4.1171. PubMed PMID: 11285321.

Anthony TG, Anthony JC, Lewitt MS, Donovan SM, Layman DK. Time course changes in IGFBP-1 after treadmill exercise and postexercise food intake in rats. Am J Physiol Endocrinol Metab. 2001 Apr;280(4):E650-6. doi: 10.1152/ajpendo.2001.280.4.E650. PubMed PMID: 11254473.

Anthony JC, Anthony TG, Kimball SR, Jefferson LS. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr. 2001 Mar;131(3):856S-860S. doi: 10.1093/jn/131.3.856S. Review. PubMed PMID: 11238774.

Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr. 2000 Oct;130(10):2413-9. doi: 10.1093/jn/130.10.2413. PubMed PMID: 11015466.

Anthony TG, Fabian JR, Kimball SR, Jefferson LS. Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. Biochim Biophys Acta. 2000 Jun 21;1492(1):56-62. doi: 10.1016/s0167-4781(00)00062-2. PubMed PMID: 10858531.

Anthony JC, Anthony TG, Kimball SR, Vary TC, Jefferson LS. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J Nutr. 2000 Feb;130(2):139-45. doi: 10.1093/jn/130.2.139. PubMed PMID: 10720160.

Anthony JC, Anthony TG, Layman DK. Leucine supplementation enhances skeletal muscle recovery in rats following exercise. J Nutr. 1999 Jun;129(6):1102-6. doi: 10.1093/jn/129.6.1102. PubMed PMID: 10356072.

Gautsch TA, Kandl SM, Donovan SM, Layman DK. Growth hormone promotes somatic and skeletal muscle growth recovery in rats following chronic protein-energy malnutrition. J Nutr. 1999 Apr;129(4):828-37. doi: 10.1093/jn/129.4.828. PubMed PMID: 10203557.

Gautsch TA, Kandl SM, Donovan SM, Layman DK. Response of the IGF-I system to prolonged undernutrition and its involvement in somatic and skeletal muscle growth retardation in rats. Growth Dev Aging. 1998 Spring-Summer;62(1-2):13-25. PubMed PMID: 9666353.

Gautsch TA, Anthony JC, Kimball SR, Paul GL, Layman DK, Jefferson LS. Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise. Am J Physiol. 1998 Feb;274(2):C406-14. doi: 10.1152/ajpcell.1998.274.2.C406. PubMed PMID: 9486130.